Ontology Collection, GO:0019725y cellular homeostasis # accession total log(e) description "1", "YEL031W", "541", "-554.6", "P-type ATPase - unknown function, SPF1, protein amino acid glycosylation, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, endoplasmic reticulum membrane" "2", "YDL185W", "1175", "-444.8", "encodes 3 region protein which is self-spliced into TFP1p and PI-SceI, TFP1, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane (sensu Fungi)" "3", "YBR127C", "894", "-410.4", "H+-ATPase V1 domain 60 KD subunit, vacuolar, VMA2, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, cytoplasm" "4", "YLR109W", "1083", "-330.6", "Alkyl hydroperoxide reductase, AHP1, regulation of cell redox homeostasis, thioredoxin peroxidase activity, cytoplasm" "5", "YOR270C", "459", "-326.5", "H+-ATPase V0 domain 95K subunit, vacuolar, VPH1, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuole" "6", "YML028W", "934", "-324.1", "thiol-specific antioxidant, TSA1, response to oxidative stress, thioredoxin peroxidase activity, cytoplasm" "7", "YMR105C", "470", "-268.1", "phosphoglucomutase, major isoform, PGM2, glucose 1-phosphate utilization, phosphoglucomutase activity, cytosol" "8", "YJR104C", "684", "-230.9", "copper-zinc superoxide dismutase, SOD1, zinc ion homeostasis, copper, zinc superoxide dismutase activity, cytosol" "9", "YML057W", "146", "-224.8", "calcineurin B, catalytic subunit, CMP2, cell ion homeostasis, calcium-dependent protein serine/threonine phosphatase activity, cytoplasm" "10", "YKL080W", "519", "-214.1", "H+-ATPase V1 domain 42 KD subunit, vacuolar, VMA5, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane (sensu Fungi)" "11", "YDR353W", "718", "-201.3", "thioredoxin reductase (NADPH), TRR1, regulation of cell redox homeostasis, thioredoxin-disulfide reductase activity, cytoplasm" "12", "YOR267C", "105", "-193.2", "similarity to ser/thr protein kinases, HRK1, cell ion homeostasis, protein kinase activity, cytoplasm" "13", "YPR036W", "508", "-192.1", "H+-ATPase V1 domain 54 KD subunit, vacuolar, VMA13, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane (sensu Fungi)" "14", "YLR433C", "63", "-180.9", "calcineurin B, catalytic subunit, CNA1, cell wall organization and biogenesis, calcium-dependent protein serine/threonine phosphatase activity, cytoplasm" "15", "YLR447C", "329", "-179.7", "H+-ATPase V0 domain 36 KD subunit, vacuolar, VMA6, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane" "16", "YDL198C", "181", "-177.1", "Protein of the mitochondrial carrier family (MCF) - role in cellular iron homoeostasis, GGC1, iron ion homeostasis, guanine nucleotide transporter activity, mitochondrial inner membrane" "17", "YER133W", "460", "-168.7", "ser/thr phosphoprotein phosphatase 1, catalytic chain, GLC7, 35S primary transcript processing, protein phosphatase type 1 activity, nucleolus" "18", "YOL027C", "177", "-160.6", "similarity to YPR125w, MDM38, mitochondrion organization and biogenesis, molecular_function unknown, mitochondrion" "19", "YDL022W", "631", "-156.3", "glycerol-3-phosphate dehydrogenase (NAD+), cytoplasmic, GPD1, intracellular accumulation of glycerol, glycerol-3-phosphate dehydrogenase (NAD+) activity, cytoplasm" "20", "YOR332W", "588", "-150", "H+-ATPase V1 domain 27 KD subunit, vacuolar, VMA4, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane (sensu Fungi)" "21", "YDR328C", "184", "-141.3", "kinetochore protein complex CBF3, subunit D, SKP1, ubiquitin-dependent protein catabolism, protein binding, cytoplasm" "22", "YOR061W", "250", "-134.7", "casein kinase II alpha^ chain, CKA2, protein amino acid phosphorylation, protein kinase CK2 activity, protein kinase CK2 complex" "23", "YMR058W", "190", "-131.2", "cell surface ferroxidase, high affinity, FET3, high affinity iron ion transport, ferroxidase activity, plasma membrane" "24", "YKL040C", "125", "-125.7", "iron homeostasis, NFU1, iron ion homeostasis, molecular_function unknown, mitochondrial matrix" "25", "YHR039C-A", "351", "-122.4", "H+-transporting ATPase V0 domain 13 KD subunit, vacuolar, VMA10, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, hydrogen-transporting ATPase V1 domain" "26", "YDR513W", "390", "-107.5", "glutaredoxin, TTR1, response to oxidative stress, thiol-disulfide exchange intermediate activity, mitochondrion" "27", "YIL035C", "86", "-101.2", "casein kinase II, catalytic alpha chain, CKA1, protein amino acid phosphorylation, protein kinase CK2 activity, protein kinase CK2 complex" "28", "YGR209C", "591", "-100.9", "thioredoxin II, TRX2, response to oxidative stress, thiol-disulfide exchange intermediate activity, cytosol" "29", "YLR043C", "496", "-98.6", "thioredoxin I, TRX1, response to oxidative stress, thiol-disulfide exchange intermediate activity, cytosol" "30", "YMR243C", "221", "-96.1", "Vacuolar transporter of zinc (and possibly other metals), ZRC1, zinc ion homeostasis, di-, tri-valent inorganic cation transporter activity, vacuole (sensu Fungi)" "31", "YGL006W", "109", "-94.7", "Vacuolar P-type ATPase transporting Ca++ into the vacuole, PMC1, calcium ion transport, calcium-transporting ATPase activity, vacuolar membrane (sensu Fungi)" "32", "YGL019W", "108", "-93.9", "casein kinase II, beta subunit, CKB1, protein amino acid phosphorylation, protein kinase CK2 activity, protein kinase CK2 complex" "33", "YCL035C", "324", "-89.2", "glutaredoxin, GRX1, response to oxidative stress, thiol-disulfide exchange intermediate activity, cytoplasm" "34", "YPL224C", "40", "-87.9", "Mitochondrial iron transport protein, MMT2, iron ion homeostasis, molecular_function unknown, mitochondrion" "35", "YMR177W", "28", "-86.6", "Mitochondrial iron transport protein, MMT1, iron ion homeostasis, molecular_function unknown, mitochondrion" "36", "YBL064C", "181", "-81.8", "mitochondrial isoform of thioredoxin peroxidase, PRX1, regulation of cell redox homeostasis, thioredoxin peroxidase activity, mitochondrion" "37", "YMR301C", "44", "-80.9", "Mitochondrial inner membrane, ^half-size^ ABC transporter involved in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins, ATM1, iron ion homeostasis, ATPase activity, coupled to transmembrane movement of substances, mitochondrial inner membrane" "38", "YER145C", "61", "-80.9", "High affinity iron transporter, FTR1, high affinity iron ion transport, iron ion transporter activity, plasma membrane" "39", "YOR039W", "109", "-76.9", "casein kinase II beta^ chain, CKB2, protein amino acid phosphorylation, protein kinase CK2 activity, protein kinase CK2 complex" "40", "YGR020C", "124", "-76.7", "H+-ATPase V1 domain 14 kDa subunit, vacuolar, VMA7, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane (sensu Fungi)" "41", "YGR092W", "27", "-69.8", "ser/thr protein kinase related to Dbf20p, DBF2, protein amino acid phosphorylation, protein serine/threonine kinase activity, bud neck" "42", "YGL020C", "102", "-69.1", "weak similarity to TRCDSEMBL:SPBC543_10 putative coiled-coil protein S. pombe, MDM39, mitochondrion organization and biogenesis, molecular_function unknown, endoplasmic reticulum" "43", "YEL051W", "151", "-67.3", "H+-ATPsynthase V1 domain 32 KD subunit, vacuolar, VMA8, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, vacuolar membrane (sensu Fungi)" "44", "YDR453C", "323", "-65.7", "thiol peroxidase , TSA2, regulation of cell redox homeostasis, thioredoxin peroxidase activity, nucleus" "45", "YKL190W", "93", "-65", "calcineurin B, regulatory subunit, CNB1, cell wall organization and biogenesis, calcium-dependent protein serine/threonine phosphatase activity, cytoplasm" "46", "YOR316C", "35", "-61.7", "Vacuolar zinc (and possibly other metals) transporter, COT1, zinc ion homeostasis, di-, tri-valent inorganic cation transporter activity, vacuole (sensu Fungi)" "47", "YKL175W", "46", "-61.7", "Vacuolar zinc efflux protein, ZRT3, zinc ion homeostasis, zinc ion transporter activity, vacuolar membrane" "48", "YCL017C", "161", "-60.5", "regulates Iron-Sulfur cluster proteins, cellular Iron uptake, andIron distribution, NFS1, iron ion homeostasis, cystathionine gamma-lyase activity, mitochondrion" "49", "YDR205W", "32", "-59.5", "similarity to A.eutrophus cation efflux system membrane protein czcD, rat zinc transport protein ZnT-1 and Cot1p, MSC2, zinc ion homeostasis, cation:cation antiporter activity, nucleus" "50", "YHR060W", "44", "-53.9", "vacuolar ATPase assembly protein, VMA22, protein complex assembly, unfolded protein binding, endoplasmic reticulum membrane" "51", "YLR220W", "34", "-53.5", "Proposed vacuolar iron transport protein, CCC1, iron ion homeostasis, molecular_function unknown, Golgi apparatus" "52", "YLR034C", "86", "-52.7", "strong similarity to SMF2 protein and S.pombe hypothetical protein, SMF3, intracellular iron ion storage, iron ion transporter activity, vacuolar membrane (sensu Fungi)" "53", "YDR182W", "50", "-51.5", "cell division control protein, CDC1, DNA repair, molecular_function unknown, integral to membrane" "54", "YML016C", "157", "-49.9", "ser/thr phosphatase required for normal osmoregulation, PPZ1, sodium ion homeostasis, protein serine/threonine phosphatase activity, cytoplasm" "55", "YDL120W", "32", "-46.9", "regulates mitochondrial iron accumulation, YFH1, iron ion homeostasis, enzyme regulator activity, mitochondrion" "56", "YHR106W", "247", "-45.7", "thioredoxin reductase, TRR2, response to oxidative stress, thioredoxin-disulfide reductase activity, mitochondrion" "57", "YDR098C", "266", "-44.3", "member of the subfamily of yeast glutaredoxins (Grx3, Grx4, and Grx5), GRX3, response to oxidative stress, thiol-disulfide exchange intermediate activity, intracellular" "58", "YJR033C", "63", "-43.9", "similarity to Drosophila DmX gene, RAV1, vacuolar acidification, molecular_function unknown, cytoplasm" "59", "YMR054W", "77", "-41.7", "H+-ATPase V0 domain 102 KD subunit, not vacuolar, STV1, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, Golgi apparatus" "60", "YJL165C", "63", "-36.2", "ser/thr protein kinase, HAL5, cation homeostasis, protein kinase activity, cellular_component unknown" "61", "YJR059W", "86", "-34.2", "involved in polyamine uptake, PTK2, G1/S transition of mitotic cell cycle, protein kinase activity, cytoplasm" "62", "YGR029W", "15", "-33.6", "mitochondrial biogenesis and regulation of cell cycle, ERV1, iron ion homeostasis, thiol oxidase activity, mitochondrion" "63", "YOR087W", "59", "-33.5", "vacuolar cation channel, YVC1, cation homeostasis, potassium channel activity, vacuole (sensu Fungi)" "64", "YDR495C", "29", "-32.8", "vacuolar sorting protein, VPS3, protein-vacuolar targeting, molecular_function unknown, cytoplasm" "65", "YOR054C", "64", "-32.4", "similarity to Sis2p protein and C.tropicalis hal3 protein, VHS3, G1/S transition of mitotic cell cycle, phosphopantothenoylcysteine decarboxylase activity, cellular_component unknown" "66", "YLL051C", "18", "-31.6", "strong similarity to ferric reductase Fre2p, FRE6, biological_process unknown, ferric-chelate reductase activity, vacuole (sensu Fungi)" "67", "YDR376W", "20", "-30.8", "mitochondrial protein with similarity to human adrenodoxin reductase and ferredoxin-NADP+ reductase, ARH1, iron ion homeostasis, NADPH-adrenodoxin reductase activity, mitochondrial inner membrane" "68", "YLR369W", "104", "-29.9", "mitochondrial heat shock protein 70, SSQ1, DNA-dependent DNA replication, unfolded protein binding, mitochondrial matrix" "69", "YEL027W", "52", "-29.4", "H+-ATPase V0 domain 17 KD subunit, vacuolar, CUP5, protein-vacuolar targeting, hydrogen ion transporter activity, hydrogen-transporting ATPase V0 domain" "70", "YNL259C", "50", "-26.7", "antioxidant protein and metal homeostasis factor, ATX1, response to oxidative stress, copper chaperone activity, cytosol" "71", "YKL134C", "20", "-26.3", "mitochondrial intermediate peptidase, OCT1, iron ion homeostasis, metallopeptidase activity, mitochondrion" "72", "YPL234C", "83", "-26.2", "H+-ATPase V0 domain 17 KD subunit, vacuolar, TFP3, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, hydrogen-transporting ATPase V0 domain" "73", "YDR436W", "129", "-24.6", "protein ser/thr phosphatase of the PP-1 family, PPZ2, sodium ion homeostasis, protein serine/threonine phosphatase activity, cellular_component unknown" "74", "YDL128W", "56", "-24.4", "Vacuolar Ca++/H+ exchanger, VCX1, calcium ion transport, calcium ion transporter activity, vacuole (sensu Fungi)" "75", "YER174C", "149", "-23.7", "member of the subfamily of yeast glutaredoxins (Grx3, Grx4, and Grx5), GRX4, response to oxidative stress, thiol-disulfide exchange intermediate activity, intracellular" "76", "YLR126C", "22", "-22.8", "weak similarity to P.aeruginosa anthranilate synthase component II, biological_process unknown, molecular_function unknown, cytoplasm" "77", "YIL010W", "52", "-22.2", "involved in derepression of telomeric silencing, DOT5, regulation of cell redox homeostasis, thioredoxin peroxidase activity, nucleus" "78", "YMR216C", "41", "-22", "similarity to S.pombe dsk1, human SRPK1 and other protein kinases, SKY1, response to drug, protein kinase activity, cytoplasm" "79", "YBR295W", "22", "-21.1", "P-type ATPase similar to the copper-transporting P-type ATPase Ccc2p - controls intracellular cadmium level by enhancing cadmium efflux, PCA1, iron ion homeostasis, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, membrane" "80", "YJR040W", "13", "-20.1", "Chloride channel of Golgi and endosomal compartments, GEF1, cation homeostasis, voltage-gated chloride channel activity, Golgi vesicle" "81", "YKL119C", "16", "-19.4", "H+-ATPase assembly protein, VPH2, protein complex assembly, molecular_function unknown, endoplasmic reticulum membrane" "82", "YDR515W", "13", "-19.4", "La motif-containing proteins that modulate mRNA translation, SLF1, regulation of translation, RNA binding, cytoplasm" "83", "YOL060C", "53", "-19.3", "similarity to hypothetical C.elegans and A.thaliana hemolysin like proteins, MAM3, mitochondrion organization and biogenesis, molecular_function unknown, vacuolar membrane (sensu Fungi)" "84", "YHR026W", "24", "-18.2", "H+-ATPase 23 KD subunit, vacuolar, PPA1, vacuolar acidification, hydrogen-transporting ATPase activity, rotational mechanism, hydrogen-transporting ATPase V0 domain" "85", "YJL056C", "22", "-18", "metalloregulatory protein involved in zinc-responsive transcriptional regulation, ZAP1, regulation of transcription from Pol II promoter, DNA binding, nucleus" "86", "YOL158C", "25", "-17.2", "Transporter of the siderophore enterobactin, ENB1, ferric-enterobactin transport, ferric-enterobactin transporter activity, integral to membrane" "87", "YCR044C", "14", "-16.7", "involved in manganese homeostasis, PER1, response to unfolded protein, molecular_function unknown, vacuolar membrane (sensu Fungi)" "88", "YCR008W", "23", "-16.6", "serine/threonine-specific protein kinase, SAT4, G1/S transition of mitotic cell cycle, protein kinase activity, cellular_component unknown" "89", "YHL040C", "9", "-14.6", "Transporter of ferrirubin, ferrirhodin and other ferrichromes, ARN1, iron-siderochrome transport, siderochrome-iron transporter activity, endosome" "90", "YJR049C", "23", "-13.8", "associated with ferric reductase activity, UTR1, iron ion homeostasis, NAD+ kinase activity, cytoplasm" "91", "YLR138W", "31", "-13.4", "Na+/H+ exchanger (also harbouring K+/H+ activity), NHA1, monovalent inorganic cation homeostasis, cation:cation antiporter activity, plasma membrane" "92", "YKR007W", "13", "-12.9", "weak similarity to Streptococcus protein M5 precursor, MEH1, biological_process unknown, molecular_function unknown, vacuolar membrane (sensu Fungi)" "93", "YBR036C", "34", "-12.7", "calcium dependent regulatory protein, CSG2, calcium ion homeostasis, enzyme regulator activity, integral to endoplasmic reticulum membrane" "94", "YOR226C", "9", "-12.7", "strong similarity to nitrogen fixation proteins, ISU2, iron ion homeostasis, molecular_function unknown, mitochondrial matrix" "95", "YPL135W", "43", "-12.7", "strong similarity to nitrogen fixation protein (nifU), ISU1, iron ion homeostasis, protein binding, mitochondrion" "96", "YCL005W-A", "5", "-10.5", "Subunit e of the Vo (membrane) sector of the vacuolar H+-ATPase, essential for vacuolar acidification, VMA9, vacuolar acidification, ATPase activity, coupled to transmembrane movement of ions, vacuolar membrane" "97", "YGL155W", "14", "-10.5", "geranylgeranyltransferase beta subunit, CDC43, establishment of cell polarity (sensu Saccharomyces), signal transducer activity, intracellular" "98", "YDR456W", "11", "-10.4", "Na+/H+ exchanger of the prevacuolar compartment - involved in salt tolerance, NHX1, vacuolar acidification, monovalent inorganic cation transporter activity, late endosome" "99", "YDR270W", "16", "-9.5", "P-type ATPase involved in export of Cu++ from the cytosol into intracellular, secretory compartments, CCC2, intracellular copper ion transport, copper-exporting ATPase activity, Golgi trans face" "100", "YDR202C", "12", "-9.2", "hypothetical protein, RAV2, vacuolar acidification, molecular_function unknown, hydrogen-transporting ATPase V1 domain" "101", "YKR050W", "10", "-8.7", "Potassium transporter II, TRK2, potassium ion homeostasis, potassium ion transporter activity, plasma membrane" "102", "YJL129C", "24", "-8.6", "Potassium transporter I, TRK1, potassium ion homeostasis, potassium ion transporter activity, plasma membrane" "103", "YLR023C", "8", "-7.9", "Implicated in Zinc Homeostasis, membran protein, IZH3, lipid metabolism, metal ion binding, endoplasmic reticulum" "104", "YJL093C", "9", "-7.9", "Voltage-gated, outward-rectifying K+ channel protein of the plasma membrane, TOK1, potassium ion homeostasis, potassium channel activity, plasma membrane" "105", "YML132W", "12", "-7.6", "strong similarity to subtelomeric encoded proteins, COS3, biological_process unknown, molecular_function unknown, vacuole (sensu Fungi)" "106", "YDR492W", "2", "-7.5", "Implicated in Zinc Homeostasis, membran protein, IZH1, lipid metabolism, metal ion binding, endoplasmic reticulum" "107", "YPL202C", "4", "-6.3", "similarity to cell size regulation protein Rcs1p, AFT2, transcription initiation from Pol II promoter, specific RNA polymerase II transcription factor activity, nucleus" "108", "YPL177C", "1", "-6.2", "involved in copper homeostasis repression of protein import, CUP9, transcription initiation from Pol II promoter, specific RNA polymerase II transcription factor activity, nucleus" "109", "YHL047C", "11", "-4.5", "Transporter of the fungal siderophore triacetylfusarinine C, ARN2, iron ion homeostasis, siderochrome-iron transporter activity, plasma membrane" "110", "YMR021C", "9", "-4.2", "metal binding activator, MAC1, positive regulation of transcription from Pol II promoter, specific RNA polymerase II transcription factor activity, nucleus" "111", "YDL142C", "3", "-4.2", "cardiolipin synthase, CRD1, lipid biosynthesis, cardiolipin synthase activity, mitochondrial membrane" "112", "YLR047C", "5", "-4.2", "similarity to hypothetical protein YGL160w, biological_process unknown, oxidoreductase activity, oxidizing metal ions, cellular_component unknown" "113", "YMR134W", "9", "-4.1", "hypothetical protein, iron ion homeostasis, molecular_function unknown, cytoplasm" "114", "YDR065W", "7", "-2.9", "hypothetical protein, biological_process unknown, molecular_function unknown, mitochondrion" "115", "YFR055W", "13", "-2.4", "strong similarity to beta-cystathionases, copper ion homeostasis, cystathionine beta-lyase activity, cellular_component unknown" "116", "YML006C", "10", "-2.4", "hypothetical protein, GIS4, intracellular signaling cascade, molecular_function unknown, cytoplasm" "117", "YOR147W", "7", "-2.1", "similarity to YHR194w, MDM32, mitochondrion organization and biogenesis, molecular_function unknown, mitochondrion" "118", "YLR205C", "4", "-2.1", "weak similarity to heme oxygenase ^Rhodella violacea HO_RHOVL^, HMX1, iron ion homeostasis, peroxidase activity, endoplasmic reticulum" "119", "YOR079C", "2", "-2", "Putative Golgi transporter involved in homeostasis of manganese ions, ATX2, manganese ion homeostasis, manganese ion transporter activity, Golgi membrane" "120", "YOL101C", "3", "-1.8", "Implicated in Zinc Homeostasis, membran protein, IZH4, lipid metabolism, metal ion binding, membrane" "121", "YEL065W", "7", "-1.7", "Transporter of the bacterial siderophore ferrioxamine B, SIT1, iron ion homeostasis, siderochrome-iron (ferrioxamine) uptake transporter activity, endosome" "122", "YOR381W", "2", "-1.6", "strong similarity to ferric reductase Fre2p, FRE3, iron ion homeostasis, ferric-chelate reductase activity, plasma membrane" "123", "YHR194W", "4", "-1.4", "similarity to hypothetical protein YOR147w, MDM31, mitochondrion organization and biogenesis, molecular_function unknown, nucleus" "124", "YJL059W", "3", "-1.4", "may function as a chaperone, similarity to human Batten disease-related protein CLN3, YHC3, intracellular protein transport, basic amino acid transporter activity, vacuole (sensu Fungi)" "125", "YOL002C", "2", "-1.4", "Implicated in Zinc Homeostasis, membran protein, IZH2, lipid metabolism, metal ion binding, membrane" "126", "YLR136C", "7", "-1.4", "tRNA-specific adenosine deaminase 3, TIS11, biological_process unknown, molecular_function unknown, cytoplasm" "127", "YNR060W", "2", "-1", "strong similarity to Fre2p, and similarity to Fre1p, FRE4, iron-siderochrome transport, ferric-chelate reductase activity, plasma membrane" "128", "YDR151C", "1", "0", "strong similarity to CCCH zinc finger protein Tis11p, CTH1, transcription, transcription factor activity, nucleus" "129", "YCL058C", "3", "0", "hypothetical protein, FYV5, cell ion homeostasis, molecular_function unknown, cellular_component unknown" out of 130